Author(s): A Khaleel Ahmed, Abdul Mobeen and MA Quamri

Abstract:
Urticaria consists of blancheable, erythematous, oedematous papules or ‘Weals’. It is estimated that lifetime incidence of urticaria is approximately 20%. It is more common among females than males. Urticaria may be classified on the basis of underlying aetiology or by a clinical classification. Main cause of Urticaria is immunoglobulin E- and non-immunoglobulin E-mediated release of histamine and other inflammatory mediators from mast cells and basophils. Although often self-limited and benign, it can cause significant discomfort, continue for months to years, and uncommonly represent a serious systemic disease or life-threatening allergic reaction. Diagnosis is made by clinically; anaphylaxis must be ruled out if needed. In about 50% of patients urticaria occurs alone where as about 40% of patients urticaria occurs with angioedema and in about 10% of patients angioedema occurs alone. The mainstay of treatment is avoidance of pollen grains or triggers, if identified. The first-line therapy is second-generation H₁ anti-histamines, which can be titrated to greater than standard doses whereas first-generation H₁ antihistamines, H₂ antihistamines, leukotriene receptor antagonists, high-potency antihistamines, and corticosteroid (pulse therapy) bursts may be used as adjunctive treatment. In case of refractory chronic urticaria, patients can be referred to super specialist for additional treatments approach, like omalizumab or cyclosporine. Using of Unani Medicine is highly effective for the management of urticaria which is based upon multidimensional approach i.e. dietotherapy (avoiding consumption of Ghaleez and Fasid Ghiza), regimes (evacuates morbid/toxins materials from the body with the help of diaphoresis, hijama, fasd, huqna, Idrar etc.) and pharmacotherapy (Islah-e-Jigar, Musaffi Dam and Moaddilat-e-Dam).

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