Aim: We undertook this study to find out the efficacy of unani drug sharbat ustukhudus in the management of nazla muzmin (chronic rhinosinusitis).

Material & Methods: Study was conducted on 30 patients having various subjective and objective parameters, confirmed by comprehensive general, systemic examination as well as the local examination of nose and paranasal sinuses and diagnosis was confirmed on the basis of X-ray PNS (water’s view),which was carried out before and after the treatment.

Study Design & duration: The study was designed as open, randomized clinical trial. Subjects were randomly allocated from AKTC Hospital, either from IPD or OPDs. The treatment period of test drug was six weeks. The study was divided into six visits (7th, 14 th, 21th, 28th, 35 th, 42 th wks) of follow up which were made at an interval of one week.

Results: Test drug was found to be effective on subjective parameters as well as on objective parameters, it significantly reduce sinus tenderness & sinus opacity after treatment which were the main objective parameters.